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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Neurobiol Learn Mem. 2018 Nov 5;156:103–116. doi: 10.1016/j.nlm.2018.11.002

Fig. 8.

Fig. 8.

Experimental design for the object placement (A) and object recognition (B) subthreshold inactivation experiments. Doses of CNO and SALB that do not impair memory on their own impair OP (C) and OR (D) memory when co-administered to mice expressing KORD in the DH and hM4Di in the mPFC. Subthreshold doses of SALB (5 mg/kg) and CNO (1 mg/kg) do not impair memory in control mice in either task. This finding suggests that concurrent neural activity in both the DH and the mPFC is necessary for the consolidation of spatial and object recognition memories. Bars represent the mean ± SEM, *p < 0.05 relative to chance or the Control group.