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. 2020 Jun 23;22:156. doi: 10.1186/s13075-020-02239-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The alterations in SLE signaling pathway based on calculated final parameters. The representation design of KEGG-extracted SLE signaling pathways (a), genes involved in autoantigen clearance (b), antigen presentation mediated by MHCII (c), and tissue injury and end-organ damage (d). The color and size of nodes reflect the values and the absolute values of the μ^∗(β_f), respectively, and it is equivalent to the upregulation or downregulation of genes. Moreover, the color of the edges reflects the values of the μ^∗(β_f), respectively, and it is equivalent to the increasing or decreasing biological function