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The top three nodes and edges of the studied pathways
| Nodes | Edges | |||
|---|---|---|---|---|
| Down | Up | Increasing biological function | Decreasing biological function | |
| SLE | SNRPD3 | FCGR1A | C1R → C4A | C1QA → C2 |
| HLA-DPB1 | CTSG | C1QB → C4A | CD86 → CD28 | |
| HLA-DMA | ELANE | C4B → C3 | C1S → C4A | |
| TCR | CD3E | BCL10 | RASGRP1 → NRAS | NCK2 → PAK3 |
| PPP3CC | PAK5 | CBLB→FYN | MAP2K1 → MAPK1 | |
| CBLB | MAPK14 | PPP3CB → NFATC3 | CD3E → FYN | |
| BCR | INPP5D | BCL10 | AKT3 → IKBKG | SYK → PIK3AP1 |
| PPP3CC | PIK3AP1 | MAPK1 → FOS | MAP2K1 → MAPK1 | |
| CD81 | IFITM1 | PPP3CC → NFATC1 | VAV1 → RAC2 | |
