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. 2020 Jun 22;18:250. doi: 10.1186/s12967-020-02415-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Atypical extracellular vesicles in cerebrospinal fluid of patients with different central nervous system (CNS) status. a Transmission electron microscopy (TEM) images of a cerebrospinal fluid (CSF) sample from a CNS⁺ patient with precursor B-cell acute lymphoblastic leukemia (pB-ALL) depict several small extracellular vesicles (EVs). Inserted panels show the absence of CD63/CD81 immunogold labelling which is a key feature of these EVs. b TEM images taken from the CSF sample of a patient with CNS^‒ pB-ALL. Appearance of gold particles refer to CD63 (10 nm) and CD81 (5 nm) positivity of the EVs. c Small EVs in a patient with relapsed CNS⁺ T-cell ALL show mainly the absence of CD63/CD81 immunogold labelling. d CD63⁺/CD81⁺ small EVs in CSF from a patient with T-cell ALL without CNS involvement. Conversely, inserted slide shows a conglomerate of EVs without typical markers of exosomes originating from multivesicular body