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. 2020 Jun 23;22:69. doi: 10.1186/s13058-020-01303-9

Table 4.

Association of PD-L1 staining with clinicopathologic factors in triple-negative patients with neoadjuvant chemotherapy

TC TCIC IC sTIL level
Factors Negative Positive Fisher Negative Positive Fisher Negative Positive Fisher Low High Fisher
N (%) N (%) P value N (%) N (%) P value N (%) N (%) P value N (%) N (%) P value
Age [N = 37] [N = 34] [N = 34] [N = 37]
 < 50 years 14 (93) 1 (7) 0.0557 12 (80) 3 (20) 0.0171 13 (87) 2 (13) 0.064 10 (63) 6 (38) 0.5085
 ≥ 50 years 14 (64) 8 (36) 7 (37) 12 (63) 10 (53) 9 (47) 10 (48) 11 (52)
Race/ethnicity [N = 37] [N = 34] [N = 34] [N = 37]
 Black 2 (40) 3 (60) 0.1176 2 (40) 3 (60) 0.6382 3 (60) 2 (40) 0.4917 1 (25) 3 (75) 0.6123
 White+Latino 23 (82) 5 (18) 14 (56) 11 (44) 16 (64) 9 (36) 17 (59) 12 (41)
 Others 3 (75) 1 (25) 3 (75) 1 (25) 4 (100) 0 (0) 2 (50) 2 (50)
Histologic type [N = 37] [N = 34] [N = 34] [N = 37]
 IDC 26 (79) 7 (21) 0.2436 17 (57) 13 (43) 1 20 (67) 10 (33) 1 17 (52) 16 (48) 0.6088
 Metaplastic 2 (50) 2 (50) 2 (50) 2 (50) 3 (75) 1 (25) 3 (75) 1 (25)
Histologic gradea [N = 37] [N = 34] [N = 34] [N = 37]
 2 1 (100) 0 (0) 1 1 (100) 0 (0) 1 1 (100) 0 (0) 1 2 (67) 1 (33) 1
 3 27 (75) 9 (25) 18 (55) 15 (45) 22 (67) 11 (33) 18 (53) 16 (47)
sTIL level [N = 35] [N = 32] [N = 32] NA
 < 10% 16 (84) 3 (16) 0.2453 11 (61) 7 (39) 0.4765 12 (67) 6 (33) 1
 ≥ 10% 10 (63) 6 (38) 6 (43) 8 (57) 9 (64) 5 (36)
Tumor size [N = 37] [N = 34] [N = 34] [N = 37]
 ≤ 2 cm 9 (69) 4 (31) 0.796 6 (60) 4 (40) 0.8287 7 (70) 3 (30) 1 6 (43) 8 (57) 0.158
 > 2 to 5 cm 8 (80) 2 (20) 6 (60) 4 (40) 7 (70) 3 (30) 3 (38) 5 (63)
 > 5 cm 11 (79) 3 (21) 7 (50) 7 (50) 9 (64) 5 (36) 11 (73) 4 (27)
ypN [N = 37] [N = 34] [N = 34] [N = 37]
 (y)pN0 14 (74) 5 (26) 0.5435 11 (65) 6 (35) 0.4114 13 (76) 4 (24) 0.6365 11 (61) 7 (39) 0.1457
 (y)pN1 6 (86) 1 (14) 4 (67) 2 (33) 4 (67) 2 (33) 2 (25) 6 (75)
 (y)pN2 4 (57) 3 (43) 2 (29) 5 (71) 4 (57) 3 (43) 4 (50) 4 (50)
 (y)pN3 4 (100) 0 (0) 2 (50) 2 (50) 2 (50) 2 (50) 3 (100) 0 (0)
pM [N = 37] [N = 34] [N = 34] [N = 37]
 0 25 (74) 9 (26) 0.5622 18 (58) 13 (42) 0.5714 22 (71) 9 (29) 0.239 17 (50) 17 (50) 0.2342
 1 3 (100) 0 (0) 1 (33) 2 (67) 1 (33) 2 (67) 3 (100) 0 (0)
RCB category [N = 37] [N = 34] [N = 34] [N = 37]
 I 1 (50) 1 (50) 0.4578 0 (0) 1 (100) 0.059 0 (0) 1 (100) 0.0824 1 (50) 1 (50) 0.8668
 II 16 (80) 4 (20) 13 (72) 5 (28) 15 (83) 3 (17) 12 (57) 9 (43)
 III 11 (73) 4 (27) 6 (40) 9 (60) 8 (53) 7 (47) 7 (50) 7 (50)

aHistologic grade for post-treatment tumors was based on pre-treatment grade

IDC invasive ductal carcinoma, sTIL stromal tumor infiltrating lymphocytes, RCB residual cancer burden