Table 4.
Association of PD-L1 staining with clinicopathologic factors in triple-negative patients with neoadjuvant chemotherapy
| TC | TCIC | IC | sTIL level | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factors | Negative | Positive | Fisher | Negative | Positive | Fisher | Negative | Positive | Fisher | Low | High | Fisher |
| N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | N (%) | N (%) | P value | |
| Age | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| < 50 years | 14 (93) | 1 (7) | 0.0557 | 12 (80) | 3 (20) | 0.0171 | 13 (87) | 2 (13) | 0.064 | 10 (63) | 6 (38) | 0.5085 |
| ≥ 50 years | 14 (64) | 8 (36) | 7 (37) | 12 (63) | 10 (53) | 9 (47) | 10 (48) | 11 (52) | ||||
| Race/ethnicity | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| Black | 2 (40) | 3 (60) | 0.1176 | 2 (40) | 3 (60) | 0.6382 | 3 (60) | 2 (40) | 0.4917 | 1 (25) | 3 (75) | 0.6123 |
| White+Latino | 23 (82) | 5 (18) | 14 (56) | 11 (44) | 16 (64) | 9 (36) | 17 (59) | 12 (41) | ||||
| Others | 3 (75) | 1 (25) | 3 (75) | 1 (25) | 4 (100) | 0 (0) | 2 (50) | 2 (50) | ||||
| Histologic type | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| IDC | 26 (79) | 7 (21) | 0.2436 | 17 (57) | 13 (43) | 1 | 20 (67) | 10 (33) | 1 | 17 (52) | 16 (48) | 0.6088 |
| Metaplastic | 2 (50) | 2 (50) | 2 (50) | 2 (50) | 3 (75) | 1 (25) | 3 (75) | 1 (25) | ||||
| Histologic gradea | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| 2 | 1 (100) | 0 (0) | 1 | 1 (100) | 0 (0) | 1 | 1 (100) | 0 (0) | 1 | 2 (67) | 1 (33) | 1 |
| 3 | 27 (75) | 9 (25) | 18 (55) | 15 (45) | 22 (67) | 11 (33) | 18 (53) | 16 (47) | ||||
| sTIL level | [N = 35] | [N = 32] | [N = 32] | NA | ||||||||
| < 10% | 16 (84) | 3 (16) | 0.2453 | 11 (61) | 7 (39) | 0.4765 | 12 (67) | 6 (33) | 1 | |||
| ≥ 10% | 10 (63) | 6 (38) | 6 (43) | 8 (57) | 9 (64) | 5 (36) | ||||||
| Tumor size | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| ≤ 2 cm | 9 (69) | 4 (31) | 0.796 | 6 (60) | 4 (40) | 0.8287 | 7 (70) | 3 (30) | 1 | 6 (43) | 8 (57) | 0.158 |
| > 2 to 5 cm | 8 (80) | 2 (20) | 6 (60) | 4 (40) | 7 (70) | 3 (30) | 3 (38) | 5 (63) | ||||
| > 5 cm | 11 (79) | 3 (21) | 7 (50) | 7 (50) | 9 (64) | 5 (36) | 11 (73) | 4 (27) | ||||
| ypN | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| (y)pN0 | 14 (74) | 5 (26) | 0.5435 | 11 (65) | 6 (35) | 0.4114 | 13 (76) | 4 (24) | 0.6365 | 11 (61) | 7 (39) | 0.1457 |
| (y)pN1 | 6 (86) | 1 (14) | 4 (67) | 2 (33) | 4 (67) | 2 (33) | 2 (25) | 6 (75) | ||||
| (y)pN2 | 4 (57) | 3 (43) | 2 (29) | 5 (71) | 4 (57) | 3 (43) | 4 (50) | 4 (50) | ||||
| (y)pN3 | 4 (100) | 0 (0) | 2 (50) | 2 (50) | 2 (50) | 2 (50) | 3 (100) | 0 (0) | ||||
| pM | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| 0 | 25 (74) | 9 (26) | 0.5622 | 18 (58) | 13 (42) | 0.5714 | 22 (71) | 9 (29) | 0.239 | 17 (50) | 17 (50) | 0.2342 |
| 1 | 3 (100) | 0 (0) | 1 (33) | 2 (67) | 1 (33) | 2 (67) | 3 (100) | 0 (0) | ||||
| RCB category | [N = 37] | [N = 34] | [N = 34] | [N = 37] | ||||||||
| I | 1 (50) | 1 (50) | 0.4578 | 0 (0) | 1 (100) | 0.059 | 0 (0) | 1 (100) | 0.0824 | 1 (50) | 1 (50) | 0.8668 |
| II | 16 (80) | 4 (20) | 13 (72) | 5 (28) | 15 (83) | 3 (17) | 12 (57) | 9 (43) | ||||
| III | 11 (73) | 4 (27) | 6 (40) | 9 (60) | 8 (53) | 7 (47) | 7 (50) | 7 (50) | ||||
aHistologic grade for post-treatment tumors was based on pre-treatment grade
IDC invasive ductal carcinoma, sTIL stromal tumor infiltrating lymphocytes, RCB residual cancer burden