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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Nat Chem Biol. 2017 Apr 17;13(6):668–674. doi: 10.1038/nchembio.2359

Figure 1 |. Reaction catalyzed by BioW and representative homologs.

Figure 1 |

Convergent biosynthetic pathways for the incorporation of the pimelate dicarboxylate into biotin. The pathway highlighted in the rectangle illustrates the direct ligation of pimelic acid to pimeloyl-CoA via a two-step reaction catalyzed by BioW.