Table 2.
Medical complications between AN-R and AN-BP subtypes
| Cohort (N = 281) | AN-R (N = 175) |
AN-BP (N = 106) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | % | N | % | Meana | SDa | N | % | Meana | SDa | t-testb | p value | |
| Body Temperature | ||||||||||||
| Hypothermic during stay (< 36 °C) | 168 | 60 | 110 | 65 | 35.8 | 0.1 | 58 | 35 | 35.8 | 0.2 | 1.59 | 0.11 |
| Last hospital day < 36 °C | 10 | 4–19 | 11 | 5–21 | 6084 | 0.85 | ||||||
| %IBW on last day < 36 °C | 61.5 | 6.3 | 65.8 | 7.2 | 4.12 | < .0001 | ||||||
| Heart Rate and EKG on Admission | ||||||||||||
| Heart rate (bpm) | 55.3 | 13.1 | 60.7 | 12.5 | 3.37 | 0.0009 | ||||||
| Nadir heart rate (bpm) during stay | 50.1 | 11.8 | 54.3 | 3.9 | 3.06 | 0.002 | ||||||
| QTc value (ms) | 421 | 31.4 | 436 | 37.2 | 1.41 | < .001 | ||||||
| High QTc (480–500 ms) | 7 | 3 | 2 | 29 | 5 | 71 | ||||||
| Critically high QTc (> 500 ms) | 7 | 3 | 3 | 43 | 4 | 57 | ||||||
| Junctional rhythm | 5 | 2 | 1 | 20 | 4 | 80 | ||||||
| Right axis | 58 | 21 | 40 | 69 | 18 | 31 | ||||||
| Liver Function | ||||||||||||
| All normal LFTs (AST < 41; ALT < 46 U/L) | 85 | 30 | 36 | 42 | 49 | 58 | ||||||
| Modestly Abnormal (up to 3x normal) | 101 | 36 | 60 | 59 | 41 | 41 | ||||||
| Severely abnormal (> 3x normal) | 95 | 34 | 79 | 83 | 16 | 17 | ||||||
| Highest AST | 197 | 145–348 | 238 | 136–537 | 383 | 0.76 | ||||||
| Highest ALT | 270 | 197–485 | 261 | 196–518 | 618 | 0.65 | ||||||
| Hospital day LFTs peaked | 4 | 0–12 | 5 | 0–12 | 6381 | 0.21 | ||||||
| Blood Glucose | ||||||||||||
| Hypoglycemia (< 3.3 mmol/L) | 107 | 38 | 77 | 72 | 3.0 | 2.6–3.2 | 30 | 28 | 2.9 | 2.8–3.1 | 1637 | 0.45 |
| Last hospital day glucose < 3.3 mmol/L | 2 | 1–2 | 1 | 0–2 | 1963 | 0.06 | ||||||
| Severe hypoglycemia (< 2.2 mmol/L)c | 24 | 9 | 20 | 83 | 1.8 | 1.6–2.0 | 4 | 17 | 1.9 | 1.4–2.1 | ||
| Last hospital day glucose < 2.2 mmol/L | 1 | 0–3 | 1 | 0–3 | ||||||||
AN-R Anorexia nervosa restricting subtype, AN-BP Anorexia nervosa binge-purge subtype, IBW Ideal body weight, EKG Electrocardiogram, bpm Beats per minute, LFT Liver function tests, AST Aspartate aminotransferase test, ALT Alanine aminotransferase test
aMedian (IQR) for not normally distributed variables
bMann-Whitney U test
cThere were too few values for an analysis between AN subtypes and severe hypoglycemia