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. 2020 Jun 23;18:99. doi: 10.1186/s12964-020-00591-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Distribution of proteome normalized ratios of phosphopeptides identified after 5.0 min treatment (a) and 15 min treatment (b). Intensity values of each channel of the phosphoproteome were normalized by correction factors derived from respective channels of the measured proteome. Ratios were determined by the mean of the treatment SAG or vismodegib (N = 3) divided by the mean of DMSO (N = 3) of the respective time point. SAG/DMSO (green graph) represents the distribution of the phosphopeptide ratios of SAG treatment compared with DMSO treatment, whereas Vismo/DMSO (orange graph) describes the distribution of phosphopeptide ratio of vismodegib treatment compared to control (DMSO) treatment. The ratio was determined by division of the proteome-normalized intensity by the mean of DMSO treatment. SAG/Vismo (blue graph) describes the phosphopeptide ratio generated by division of SAG/DMSO by Vismo/DMSO