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. 2020 Jun 23;18:99. doi: 10.1186/s12964-020-00591-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Ingenuity pathway analysis of all phosphopeptides identified after 5.0 min. a Comparative analysis of regulated pathways after SAG and vismodegib treatment. Pathways were manually filtered for cancer relevance and the log10 p-value cut-off was set to 1.3. Activated pathways are shown in orange, inhibited pathways in blue. b Top 12 significantly enriched pathways after 5.0 min SAG (upper bar chart) and vismodegib treatment (lower bar chart). The total number of phosphoproteins which are assigned to a particular pathway are displayed on top of the particular bar, share of those phosphoproteins identified in the experiment is represented by the primary x-axis, while the –log p-value determined by Fisher’s exact testing is represented by the secondary y-axis. The proportion of upregulated phosphoproteins is shown in orange, downregulation is indicated by blue bars