Fig. 7.

Autophagy-induced inhibition of the NLRP3 inflammasome contributes to the anti-tumor effect of Ginkgolide B (GKB). a Western blot analysis of the expression of NLRP3 protein in H1975 cells treated with GKB for 24 h. b ELISA analysis of the expression of IL-1β and IL-18 protein after LPS was used as an NLRP3 inflammasome activator in H1975 cells. c Western blot analysis of the expression of NLRP3 protein in beclin-1 knock-down H1975 cells. d ELISA analysis the expression of IL-1β and IL-18 protein in beclin-1-knockdown H1975 cells. Data shown represent the mean ± SEM of three independent experiments. ***P < 0.001, compared to the dimethyl sulfoxide (DMSO) only group