Table 3.

Inflammatory potential of diet and risk of diverticulitis in HPFS according to lifestyle characteristics^*

	Quintiles of inflammatory potential of diet score						P for interaction
	1	2	3	4	5	P for trend
Body mass index							0.68
< 25 kg/m2 (n=400†), HR (95% CI)	1.0 (ref)	1.00 (0.73, 1.36)	1.16 (0.84, 1.60)	1.01 (0.73, 1.41)	1.32 (0.96, 1.84)	0.12
≥ 25 kg/m2 (n=708), HR (95% CI)	1.0 (ref)	1.21 (0.94, 1.56)	1.20 (0.93, 1.56)	1.27 (0.99, 1.64)	1.34 (1.04, 1.72)	0.03
Vigorous activity							0.25
No (n=523), HR (95% CI)	1.0 (ref)	1.22 (0.91, 1.64)	1.23 (0.91, 1.65)	1.27 (0.95, 1.70)	1.26 (0.94, 1.69)	0.13
Yes (n=587), HR (95% CI)	1.0 (ref)	1.06 (0.81, 1.38)	1.14 (0.87, 1.50)	1.07 (0.81, 1.41)	1.39 (1.06, 1.82)	0.03

^*Inflammatory potential of diet score was adjusted for total energy using the residual method. Higher EDIP scores indicating pro-inflammatory dietary patterns whereas lower scores indicate anti-inflammatory dietary patterns.

Models were adjusted for age (continuous, years), body mass index (<22.5, 22.5–24.9, 25.0–27.4, 27.5–29.9, 30.0–34.9, ≥35.0 kg/m²), vigorous activity (0, 0.1–3.4, 3.5–10.4, 10.5–28.4, ≥28.5 MET-h/week), smoking status (never smoker, past smoker, current smoker (1–14, 15–24, ≥25 cigarettes/d)), alcohol consumption (0, 0–4.9, 5.0–9.9, 10.0–14.9, 15.0–29.9, ≥30 g/d), aspirin use (yes/no), acetaminophen use (yes/no), use of other NSAIDs (yes/no), multivitamin use (yes/no), and physical examination for symptoms or routine screening (yes/no), with omission of the effect modifier of interest in the corresponding model.

^†n indicates number of cases.