Table 4. Previous GWAS association signals in PCOS subtypes.

Variant	Locus	PCOS	Reproductive	Metabolic	Indeterminate
rs804279	GATA4/NEIL2	P = 8.0 × 10−10	P = 2.4 × 10−3	P = 9.9 × 10−2	P = 3.1 × 10−3
rs10993397	C9orf3	P = 4.6 × 10−13	P = 2.3 × 10−4	P = 6.9 × 10−5	P = 1.1 × 10−5
rs11031006	FSHB	P = 1.9 × 10−8	P = 8.8 × 10−6	P = 6.6 × 10−1	P = 3.0 × 10−10

Subtype-specific association statistics are shown for each of the SNPs that were significantly associated with PCOS in Hayes and Urbanek and colleagues [19]. P = significance as assessed by sample-size–weighted two-strata meta-analysis, adjusted for genomic inflation. Abbreviations: GWAS, genome-wide association study; PCOS, polycystic ovary syndrome.