Table 2.

The miRNA's, the target genes and their biological implications in oral submucous fibrosis [28].

miR	Target Genes	Experimental finding	Biological implication in OSF
miR-509-5p	BMPR2, CDH6, HAS3	Down regulated	Inhibits cell proliferation and migration Promotes apoptosis
miR-610	CDH1, DSC2, KRAS, MMP19, MAPK1, TIMP3	Down regulated	Has a role in forming defective collagen
miR-760	CDH4, COX10, IL6, Il6R, IGFIR, TIMP2, TGM2	Downregulated	As a predictive marker for pre-cancer
miR-455	BMP7, BMPR, DSC1, MAPK14, MAPK11, IGF1, TIMP2, TGM 3	Upregulated	Has a role in the molecular pathway of OSF
miR-623	MAPK1, MAPK11, MAPK4, MMP1, MMP8, TIMP2, IL10	Upregulated	Has a role in the excess formation of collagen