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. 2020 Jun 23;15(6):e0234913. doi: 10.1371/journal.pone.0234913

Fig 6. Perm1 activates the promoters of ERRα and its target gene through the ERRE.

Fig 6

(A) Luciferase reporter assays showing that Perm1 increases ERRE activity (TCAAGGTCA) in a dose-dependent manner, whereas mutant ERRE (mERRE, TCAGAATCA) is not be activated by Perm1. (B) Perm1 activates the ERRE within the Ndufv1 promoter (a subunit of Complex I, an ERRα target gene) in a dose-dependent manner. Note that the ERRE in mouse Ndufv1 promoter is TGAAGGTGA. (C) Perm1 does not increase the promoter activity of PGC-1α but rather represses the gene (n = 5/group). Statistics were performed using the t-test with 2 tails (*p<0.05). Error bars are ±SEM.