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. 2020 Jun 19;15:4417–4429. doi: 10.2147/IJN.S243657

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© 2020 Zhang et al.

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Cellular uptake of the NPs and the effect of EGCG-NPs on lung cancer cell proliferation. Inverted fluorescence microscopy of lung cancer cells harvested 4 h after incubation of NP containing fluorescent-PLGA (red) and counterstained with DAPI for nucleus detection (blue). RGD-NP and non-targeted NP in A549 (A) and H1299 (B). Effects of EGCG-NPs on proliferation of (C, D) A549 cells, (E, F) H1299 cells as determined by CCK8 assay at 72 h and 96 h, respectively. (G) The IC50 on A549 and H1299 cells. Means ± SDs of three independent experiments are shown. *P < 0.05.