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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: J Am Chem Soc. 2019 May 10;141(22):8891–8895. doi: 10.1021/jacs.9b01978

Figure 1.

Figure 1.

Overview of the design process. A de novo designed homodimer, with its two monomers colored in green and purple (A), is connected into a single chain (B), and docked in a C12 layer group symmetry with three parameters a, b, and θ (C), resulting in a 2D lattice (D). Intersubunit binding interfaces are designed with hydrogen bond networks to confer specificity, show here as an example between the green and blue building blocks (E). (F) A 1.74 Å resolution crystal structure of the design SC_2L4HC2_23 (PDB ID 6EGC, white) superimposed onto the design model (rainbow); the design model deviates from the crystal by 1.08 Å RMSD.