Relative risks (with 95% CIs in round brackets) above the diagonal pertain to recurrent VTE (transparent background), whereas estimates below the diagonal pertain to major bleeding (gray background). The reference category for the respective comparison is always higher to the left, e.g. the RR of 0.72 (bottom left box) represents the comparison of VKA with DOAC using VKA as the reference. Here, an RR of 0.72 is in favor of DOAC. (2A) Estimates from the unadjusted network meta-analysis. (2B) Estimates from a network meta-analysis adjusted to a 10% six-month risk of recurrent VTE in the VKA arm (efficacy), and a 5% six-month risk of major bleeding in the VKA arm (safety).
