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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Nat Rev Immunol. 2019 Mar 1;19(3):141–153. doi: 10.1038/s41577-018-0117-0

Figure 3. Pathways in DNA-stimulated cell death.

Figure 3

(A) Cell death pathways stimulated by AIM2 in response to DNA sensing. (B) Cell-autonomous death pathways stimulated through STING-dependent mechanisms. (C) Stimulation of apoptosis and necroptosis by STING-dependent paracrine signaling. Abbreviations not defined in the text: IFNAR, IFNα receptor; ISGF, IFN-stimulated gene factor; NF, nuclear factor; PUMA, p53 upregulated modulator of apoptosis; RIPA, RLR-induced IRF-3-mediated pathway of apoptosis; TNFR, TNF receptor.