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Overexpression or knockdown of TDO inhibited or promoted tumour formation in nude mice. Representative photographs of subcutaneous tumour xenografts (A and B). Xenograft weight (C and D). Xenograft volume (E and F). Ki67 expression in subcutaneous xenograft tumors of Huh7 and LM3 cells was detected by IHC (G and H). Original magnification ×200. Error bars represent the SD. *P < 0.05, **P < 0.01 and ***P < 0.001.
