Table 3. Clinicopathological factors, F-SIRI, and OS: univariate and multivariate analysis (n=240).
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (yr) | 0.012 | 0.065 | |||||
| <60 | Ref. | Ref. | |||||
| ≥60 | 1.565 | 1.102–2.222 | 1.404 | 0.979–2.014 | |||
| Gender | 0.484 | NI | |||||
| Man | Ref. | ||||||
| Woman | 0.876 | 0.605–1.269 | |||||
| Tumor location | 0.152 | NI | |||||
| Diffuse | Ref. | ||||||
| Upper | 0.678 | 0.419–1.097 | |||||
| Middle | 0.529 | 0.322–0.869 | |||||
| Lower | 0.885 | 0.551–1.421 | |||||
| Tumor size | 0.001 | 0.189 | |||||
| <5 | Ref. | Ref. | |||||
| ≥5 | 1.891 | 1.302–2.748 | 1.309 | 0.876–1.958 | |||
| Differentiation | 0.367 | NI | |||||
| Well/moderate | Ref. | ||||||
| Poor/undifferentiated | 1.210 | 0.800–1.829 | |||||
| Depth of invasion | 0.001 | 0.033 | |||||
| T1/T2 | Ref. | Ref. | |||||
| T3/T4 | 2.770 | 1.528–5.022 | 2.002 | 1.058–3.791 | |||
| Lymph node involvement | <0.001 | <0.001 | |||||
| Negative | Ref. | Ref. | |||||
| Positive | 2.998 | 1.653–5.439 | 3.286 | 1.771–6.098 | |||
| TNM stage | <0.001 | NI | |||||
| I/II | Ref. | ||||||
| III | 3.082 | 1.910–4.973 | |||||
| Adjuvant chemotherapy | <0.001 | <0.001 | |||||
| No | Ref. | Ref. | |||||
| Yes | 0.440 | 0.301–0.643 | 0.358 | 0.242–0.529 | |||
| SIRI | <0.001 | NI | |||||
| <1.20 | Ref. | ||||||
| ≥1.20 | 1.999 | 1.387–2.881 | |||||
| Fibrinogen | 0.005 | NI | |||||
| <4 | Ref. | ||||||
| ≥4 | 1.681 | 1.166–2.424 | |||||
| F-SIRI score | <0.001 | <0.001 | |||||
| 0/1 | Ref. | Ref. | |||||
| 2 | 2.461 | 1.584–3.824 | 2.341 | 1.480–3.705 | |||
The bold numbers in the tables are P-values with statistical significance (<0.05).
F-SIRI = fibrinogen and systemic inflammation response index; TNM = tumor-node-metastasis; OS = overall survival; HR = hazard ratio; CI = confidence interval; SIRI = systemic inflammation response index; NI = not included; Ref. = reference.