Table 1. Association between miR-205-3p expression and clinicopathological factors.
| Clinical parameters | miR-205-3p expression | ||||
|---|---|---|---|---|---|
| Low | High | t/χ2 | P | ||
| Age (yr) | 58.56±11.51 | 63.06±8.02 | 1.461 | 0.149 | |
| Gender | 0.308 | 0.579 | |||
| Man | 33 (61.1) | 11 (68.8) | |||
| Woman | 21 (38.9) | 5 (31.3) | |||
| Location | 2.245 | 0.326 | |||
| Proximal | 10 (18.5) | 5 (31.3) | |||
| Middle | 24 (44.4) | 4 (25.0) | |||
| Distal | 20 (37.0) | 7 (43.8) | |||
| Size (cm) | 0.054 | 0.816 | |||
| ≥5 | 32 (59.3) | 10 (62.5) | |||
| <5 | 22 (40.7) | 6 (37.5) | |||
| Histology type | 7.616 | 0.055 | |||
| Papillary adenocarcinoma | 2 (3.7) | 3 (18.8) | |||
| Tubular adenocarcinoma | 36 (66.7) | 12 (75.0) | |||
| Mucinous adenocarcinoma | 4 (7.4) | 1 (6.3) | |||
| Signet-ring cell carcinoma | 12 (22.2) | 0 (0.0) | |||
| Lauren classification | 0.235 | 0.628 | |||
| Diffuse type | 34 (63.0) | 9 (56.3) | |||
| Intestinal type | 20 (37.0) | 7 (43.8) | |||
| Differentiation | 10.952 | 0.004 | |||
| Well | 0 (0.0) | 3 (18.8) | |||
| Moderately | 12 (22.2) | 4 (25.0) | |||
| Poorly | 42 (77.8) | 9 (56.3) | |||
| Invasion depth (T grade) | 37.926 | 0.000 | |||
| T1 | 0 (0.0) | 5 (31.3) | |||
| T2 | 3 (5.6) | 7 (43.8) | |||
| T3 | 32 (59.3) | 4 (25.0) | |||
| T4 | 19 (35.2) | 0 (0.0) | |||
| Lymphatic metastasis (N grade) | 50.087 | 0.000 | |||
| N0 | 1 (1.9) | 9 (56.3) | |||
| N1 | 1 (1.9) | 5 (31.3) | |||
| N2 | 16 (29.6) | 2 (12.5) | |||
| N3 | 36 (66.7) | 0 (0.0) | |||
| Distant metastasis (M grade) | 3.457 | 0.063 | |||
| M0 | 44 (81.5) | 16 (100) | |||
| M1 | 10 (18.5) | 0 (1.0) | |||
| TNM stages | 64.959 | 0.000 | |||
| I | 0 (0.0) | 8 (50.0) | |||
| II | 1 (1.9) | 8 (50.0) | |||
| III | 43 (79.6) | 0 (0.0) | |||
| IV | 10 (18.5) | 0 (0.0) | |||
| Lymphatic invasion | 34.277 | 0.000 | |||
| Yes | 53 (98.1) | 6 (37.5) | |||
| No | 1 (1.9) | 10 (62.5) | |||
| Vascular invasion | 13.547 | 0.000 | |||
| No | 5 (9.3) | 8 (50.0) | |||
| Yes | 49 (90.7) | 8 (50.0) | |||
All cases were classified according to the American Joint Committee on Cancer (2016, 8th version) pathological classification of gastric cancer. Invasion depth (T grade) grade T4 includes T4a and T4b. Lymphatic metastasis (N grade) grade N3 includes N3a and N3b. TNM grade I includes Ia and Ib, TNM grade II includes IIa and IIb, and TNM grade III includes IIIa, IIIb, and IIIc.
TNM = tumor, node, metastasis.