Figure 1:

Using two-way ANOVA (diet x sex), we determined that a high-fructose diet (HFD) beginning at weaning resulted in physiological differences in adult males and females. A) Fructose-fed female rats gained more weight than their chow-fed counterparts beginning in week 8 of diet exposure. This effect was maintained throughout the 10-week consumption period. B) The HFD altered caloric efficiency in female rats during weeks 5 and 6 on the diet. Alterations were not present in male rats. The caloric efficiency of all groups decreased over time. C) Both fructose-fed males and females displayed increased blood glucose at three timepoints across the diet period compared to chow controls. Circles represent mean ± SEM. *p<0.05.