Table 1.
Characteristics by global cognitive impairment among dialysis patients being evaluated for kidney transplantation (KT)
| Overall (N=3,630) |
Global Cognitive Impairment | |||
|---|---|---|---|---|
| Not Impaired (n=3,397) |
Impaired (n=233) |
p-value | ||
| Age, median years [IQR1 | 56.0 [45.1–65.1] | 55.6 [44.5–64.7] | 62.1 [54.1–69.8] | <0.001 |
| Female (%) | 41.2 | 41.9 | 30.0 | <0.001 |
| Race (%) | <0.001 | |||
| White | 47.7 | 49.4 | 21.9 | |
| Black | 45.5 | 43.8 | 69.1 | |
| Other | 6.9 | 6.7 | 9.0 | |
| High School or less (%) | 44.5 | 42.3 | 75.5 | <0.001 |
| BMI | 29.2 [6.0] | 29.3 [6.0] | 28.0 [5.9] | 0.03 |
| ADL Dependence (%) | 8.2 | 7.7 | 15.4 | <0.001 |
| IADL Dependence (%) | 20.5 | 19.4 | 36.2 | <0.001 |
| CCI, median [IQR] | 1 [0–3] | 1 [0–3] | 2[0–3] | 0.2 |
| Comorbidity (%) | ||||
| Myocardial infarction | 9.3 | 8.9 | 15.8 | 0.002 |
| Peripheral vascular disease | 6.4 | 6.2 | 8.7 | 0.2 |
| Cerebral vascular disease | 5.7 | 5.3 | 12.1 | <0.001 |
| Dementia | 0.4 | 0.4 | 1.1 | 0.2 |
| Chronic lung disease | 6.0 | 6.0 | 6.0 | 0.9 |
| Rheumatological disease | 6.7 | 6.9 | 4.4 | 0.2 |
| Peptic ulcer disease | 3.6 | 3.4 | 6.0 | 0.07 |
| Diabetes | 42.1 | 41.7 | 49.5 | 0.04 |
| Diabetes complication | 22.5 | 22.4 | 23.2 | 0.8 |
| Moderate/severe liver disease | 3.4 | 3.4 | 3.8 | 0.8 |
| Metastatic cancer | 1.0 | 1.0 | 1.1 | 0.9 |
| Leukemia | 0.3 | 0.3 | 0.0 | 0.4 |
| Lymphoma | 1.0 | 1.0 | 0.0 | 0.2 |
| HIV | 3.1 | 2.8 | 7.6 | <0.001 |
| Congestive heart failure | 14.1 | 13.7 | 21.7 | 0.02 |
| Cause of kidney failure (%) | 0.001 | |||
| Hypertension | 30.1 | 29.4 | 43.9 | |
| Diabetes | 21.0 | 21.0 | 21.1 | |
| Glomerular disease | 21.0 | 21.6 | 10.5 | |
| Other | 27.8 | 28.0 | 24.5 | |
| Years on dialysis, median [IQR] | 0.3 [0.0–1 8] | 0.2 [0.0–18] | 0.8 [0.0–3.2] | <0.001 |
| Prior kidney transplant (%) | 19.6 | 20.0 | 14.0 | 0.1 |
| Prior non-renal organ transplant (%) | 2.9 | 3.0 | 2.4 | 0.7 |
Values for continuous variables given as mean +/− standard deviation or median [interquartile range]. Participants were classified as cognitively impaired if they had a Modified Mini-Mental State Exam (3MS) score <80. Numbers and percentages at time of evaluation for kidney transplantation are presented unless otherwise indicated. Abbreviations: ADL, activities of daily living (including dependence in feeding, dressing, physical ambulation, bathing, toileting, or grooming); IADL, instrumental activities of daily living (including dependence in using the phone, shopping, cooking, house cleaning, washing, using transportation, managing money, or medications); CCI, Charlson comorbidity index adapted for dialysis.