Table 4.

Cumulative incidence and associations of listing, waitlist mortality, and kidney transplantation (KT) by global cognitive impairment.

Outcome by Global Cognitive Impairment	n	Unadjusted Cumulative incidence (%)			aHR, aSHR, aIRR* (95% CI)	p-value
		6 mo	1 y	3 y
Chance of Listing
Overall
Not impaired	233	50.5	59.1	63.8	1.00 (reference)
Impaired	3,397	32.0	43.7	51.5	0.75 (0.61–0.91)	0.004
Diabetes
Not impaired	1,201	52.4	63.8	69.5	1.00 (reference)
Impaired	91	42.2	57.3	65.0	0.92 (0.70–1.22)	0.6
No Diabetes
Not impaired	1,682	63.8	73.3	79.8	1.00 (reference)
Impaired	93	37.9	52.9	67.7	0.63 (0.48–0.83)	0.001
Risk of Waitlist Mortality
Overall
Not impaired	2,101	0.04	1.4	9.0	1.00 (reference)
Impaired	115	0.07	2.2	14.2	1.35 (0.83–2.18)	0.2
Diabetes
Not impaired	793	0.7	1.9	13.5	1.00 (reference)
Impaired	56	0.6	1.8	12.7	0.90 (0.48–1.70)	0.8
No Diabetes
Not impaired	1,281	0.3	0.9	6.3	1.00 (reference)
Impaired	57	0.8	2.3	16.0	2.47 (1.31–4.66)	0.01
Rate of KT
Overall
Not impaired	2,101	6.3	17.8	42.7	1.00 (reference)
Impaired	115	4.7	13.5	33.8	0.78 (0.56–1.09)	0.1
Diabetes
Not impaired	793	4.3	13.0	31.5	1.00 (reference)
Impaired	56	4.5	13.7	33.0	1.12 (0.71–1.77)	0.6
No Diabetes
Not impaired	1,281	7.8	20.9	49.8	1.00 (reference)
Impaired	57	4.9	13.6	35.1	0.58 (0.36–0.93)	0.03

Participants were classified as cognitively impaired if they had a Modified Mini-Mental State Exam (3MS) score <80. Adjusted associations were controlled for age, sex, race, diabetes, educational attainment, and the Charlson Comorbidity Index adapted for dialysis. To explore the association between each outcome and cognitive impairment by diabetes status, an interaction term was added between cognitive impairment and diabetes status. Abbreviations: HR, hazard ratio; SHR, subdistribution hazard ratio; IRR, incidence rate ratio.

^*aHR for chance of listing; aSHR for risk of waitlist mortality; IRR for rate of kidney transplantation.