TABLE 2A.
AUCs with 95% Confidence Intervals for Predictive Models
| Predictors in model | ICH on initial scan | Mass lesion: Marshall 5+6 | Marshall > 1 | ICH progression | 48-hr mortality | 28-day mortality | 6-month GOS-E ≤ 4 | 6-month DRS ≥ 7 |
|---|---|---|---|---|---|---|---|---|
| PH | 0.639 (0.535, 0.73) | 0.715 (0.551, 0.856) | 0.677 (0.501, 0.836) | 0.759 (0.629, 0.867) | 0.713 (0.49, 0.881) | 0.66 (0.504, 0.797) | 0.7 (0.602, 0.795) | 0.811 (0.718, 0.892) |
| UCH-L1 | 0.665 (0.556, 0.759) | 0.686 (0.539, 0.816) | 0.628 (0.467, 0.773) | 0.603 (0.423, 0.77) | 0.854 (0.702, 0.961) | 0.826 (0.704, 0.93) | 0.684 (0.567, 0.796) | 0.683 (0.556, 0.804) |
| MAP-2 | 0.736 (0.645, 0.831) | 0.831 (0.721, 0.924) | 0.777 (0.644, 0.9) | 0.543 (0.376, 0.702) | 0.804 (0.657, 0.916) | 0.768 (0.64, 0.875) | 0.645 (0.53, 0.754) | 0.652 (0.535, 0.75) |
| GFAP | 0.801 (0.714, 0.879) | 0.845 (0.714, 0.942) | 0.777 (0.624, 0.908) | 0.489 (0.31, 0.679) | 0.867 (0.686, 0.979) | 0.852 (0.724, 0.947) | 0.714 (0.609, 0.813) | 0.747 (0.625, 0.849) |
| All biomarkers | 0.8 (0.721, 0.882) | 0.869 (0.751, 0.962) | 0.82 (0.684, 0.94) | 0.486 (0.298, 0.676) | 0.862 (0.685, 0.971) | 0.85 (0.736, 0.945) | 0.714 (0.609, 0.804) | 0.738 (0.621, 0.84) |
| PH+UCH-L1 | 0.699 (0.602, 0.796) | 0.724 (0.577, 0.87) | 0.696 (0.518, 0.853) | 0.755 (0.607, 0.88) | 0.779 (0.566, 0.942) | 0.809 (0.679, 0.912) | 0.788 (0.701, 0.866) | 0.865 (0.8, 0.927) |
| PH+MAP-2 | 0.752 (0.662, 0.842) | 0.857 (0.765, 0.937) | 0.791 (0.636, 0.915) | 0.703 (0.557, 0.835) | 0.801 (0.57, 0.967) | 0.799 (0.64, 0.927) | 0.777 (0.679, 0.862) | 0.862 (0.791, 0.924) |
| PH+GFAP | 0.816 (0.742, 0.883) | 0.839 (0.736, 0.927) | 0.762 (0.61, 0.887) | 0.61 (0.427, 0.791) | 0.842 (0.61, 0.98) | 0.843 (0.696, 0.958) | 0.78 (0.683, 0.87) | 0.841 (0.747, 0.919) |
| PH+all biomarkers | 0.824 (0.747, 0.893) | 0.891 (0.802, 0.962) | 0.826 (0.699, 0.934) | 0.611 (0.408, 0.783) | 0.841 (0.599, 0.983) | 0.838 (0.682, 0.954) | 0.771 (0.673, 0.863) | 0.822 (0.728, 0.908) |
PH = Prehospital variables (GCS, age, gender)
UCH-L1 = Ubiquitin C-terminal hydrolase-L1
MAP-2 = Microtubule-associated protein 2
GFAP = Glial fibrillary acidic protein
ICH = Intracranial hemorrhage
GOS-E = Extended Glasgow Outcome Scale
DRS = Disability Rating Scale