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. Author manuscript; available in PMC: 2020 Oct 6.
Published in final edited form as: Nat Chem Biol. 2020 Apr 6;16(7):791–800. doi: 10.1038/s41589-020-0510-4

Figure 4 – Combinations of apoptotic and non-apoptotic cell death drugs are enriched for antagonism and single agent dominance.

Figure 4 –

(a) Example SAD combination. Drugs given at constant dose ratio and measured using SYTOX at 48 hours. Blue – SGI-1027; Red – Topotecan; Purple – Combination; Dashed black – expected given dose additivity; Dashed purple – expected given response independence. (b) Percent viability response matrix for all-by-all dose combinations. (c) Isobologram analysis of (b). Doses plotted on a linear scale with 10% isobols shown and 50% isobol highlighted with a black line. (d) 1-LF for topotecan alone at varied doses (red) or topotecan in the presence of 0.1 μM SGI-1027. Data are mean +/− SD from independent biological replicates (n = 4).