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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Radiother Oncol. 2020 Mar 27;147:8–14. doi: 10.1016/j.radonc.2020.02.022

Table 1.

Details of the normal tissue complication probability (NTCP) models used in the analysis. The Lyman-Kutcher-Burman model is abbreviated by LKB.

Model Endpoint Severity grade Type of model NTCP parameters
Marks et al. (2010) [24] Radiation pneumonitis 1–3 QUANTEC, logistic fit TD50 = 30.8 Gy, γ50 = 0.97
Appelt et al. (2014) [25] Radiation pneumonitis 1–3 Modified QUANTEC, uses clinical factors TD50 = 34.4 Gy, γ50 = 1.19
Tucker et al. (2013) [26] Radiation pneumonitis ≥3 Lyman-KutcherBurman TD50 = 43.2 Gy, 𝑚 = 0.31, 𝑛 = 0.41
Belderbos et al. (2005) [28] Acute esophageal toxicity ≥2 Lyman-Kutcher-Burman TD50 = 47 Gy, 𝑚 = 0.36, 𝑛 = 0.69
Chapet et al. (2005) [30] Acute esophageal toxicity 2–3 Lyman-Kutcher-Burman TD50 = 51 Gy, 𝑚 = 0.44, 𝑛 = 0.32
Eriksson et al. (2000) [31] Long-term cardiac failure Relative seriality model TD50 = 70.3 Gy, γ = 0.96, 𝑠 = 1
Gagliardi et al. (1996) [32] Long-term cardiac failure Relative seriality model TD50 = 52.3 Gy, γ = 1.28
𝑠 = 1