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. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: Nat Chem Biol. 2020 Feb 17;16(7):801–809. doi: 10.1038/s41589-020-0478-0

Figure 2. Telomerase releases multiple telomeric repeats in a single step.

Figure 2.

a, Representative time trajectories (120 ms per data point) of telomerase catalysis after transfer into nucleotide containing buffer (t = 0) showing processive elongation, forward (F) and reverse (R) stepping. Inset: Zoom-in of region of bottom-most example trace (in red) corresponding to the region shaded gray. b, Distribution of total tether elongation by telomerase (n = 60 traces). c, Distribution of overall elongation rate for all telomerase elongation trajectories (n = 60 traces). Inset: zoom-in around the main peak of the overall rate distribution. d, Distribution of the observed tether elongation step sizes of telomerase trajectories (n = 60 distinct tethers, 417 steps total). Inset: zoom-in around the forward step distribution peak. Arrows mark a 15 nt magnitude step size which is the expected GQ folding and unfolding step size.