Figure 3. Analysis of processive DNA synthesis and product release by telomerase.

a, Kernel density plot of next state extension vs. state extension associated with each step in Fig. 2d. The diagonal dashed white line is a guide dividing forward (above line) vs. reverse (below line) steps. The upper and lower dashed yellow lines are guides indicating 15 nt steps forward and reverse, respectively. b, Dot plot of the extension for the first 10 states of all telomerase trajectories (n = 60), including the mean extension (black) and individual trajectories (color). c, Distribution of step sizes for the first 5 steps (top) and all subsequent steps (bottom) for all trajectories (n = 60 tethers, 417 steps). Arrows mark a 15 nt magnitude step size. F_F and F_R indicate fractions of forward and reverse steps, respectively.