Table 1.
Characteristics of Survivors of OAT-ICH
| Variable | MGH ICH (n = 169) | ERICH (n = 61) | ||
|---|---|---|---|---|
| No Recurrent ICH | Recurrent ICH | No Recurrent ICH | Recurrent ICH | |
| No. of individuals | 137 | 32 | 45 | 16 |
| Demographics | ||||
| Age (mean, SD in years) | 71.8 (8.3) | 74.7 (7.0) | 69.8 (10.2) | 70.6 (8.9) |
| Sex (Male) | 75 (56) | 17 (53) | 21 (47) | 8 (50) |
| Race / Ethnicity | ||||
| - White | 105 (77) | 22 (69) | 14 (31) | 4 (25) |
| - Black | 16 (12) | 5 (16) | 16 (36) | 6 (38) |
| - Hispanic | 14 (10) | 4 (13) | 15 (33) | 6 (38) |
| - Other | 2 (1) | 1 (3) | 0 (0) | 0 (0) |
| Education (mean, SD in years) | 14.0 (3.8) | 13.0 (3.7) | 10.8 (3.5) | 11.1 (3.1) |
| Pre-ICH Medical History | ||||
| Hypertension | 104 (76) | 26 (81) | 39 (87) | 15 (94) |
| Diabetes Mellitus | 25 (18) | 6 (19) | 18 (40) | 7 (44) |
| Coronary Artery Disease | 37 (27) | 10 (31) | 15 (33) | 6 (38) |
| CHA2DS2-VASc score (median, IQR) | 5 (4 – 6) | 5 (4 – 6) | 5 (4 – 6) | 5 (4 – 6) |
| HAS-BLED score (median, IQR) | 3 (3 – 4) | 3 (3 – 4) | 3 (3 – 4) | 3 (3 – 4) |
| Genetic Data | ||||
| APOE ε2 (≥ 1 copy) | 20 (15) | 9 (28) | 7 (16) | 4 (25) |
| APOE ε4 (≥ 1 copy) | 30 (22) | 12 (38) | 10 (22) | 5 (31) |
| Acute ICH Data | ||||
| ICH Location | ||||
| - Lobar | 84 (61) | 26 (81) | 27 (60) | 11 (69) |
| - Non-Lobar | 53 (39) | 6 (19) | 18 (40) | 5 (31) |
| ICH Volume (median, IQR in cc) | 16.6 (8.8 – 26.6) | 17.6 (5.0 – 27.6) | 15.4 (7.3 – 25.5) | 16.3 (6.3 – 28.2) |
| IVH Presence | 43 (31) | 9 (28) | 15 (33) | 6 (38) |
| MRI Data | ||||
| Lobar CMB count (median, IQR) | 0 (0 – 1) | 1 (1 – 2) | 0 (0 – 1) | 1 (1 – 2) |
| Non-Lobar CMB count (median, IQR) | 0 (0 – 1) | 0 (0 – 1) | 0 (0 – 1) | 0 (0 – 1) |
| Cortical Superficial Siderosis | ||||
| - None | 130 (95) | 23 (72) | 42 (93) | 12 (75) |
| - Focal | 4 (3) | 3 (9) | 2 (4) | 1 (6) |
| - Disseminated | 3 (2) | 6 (19) | 1 (2) | 3 (19) |
| Medication Exposure During Follow-up | ||||
| OAT | 38 (28) | 8 (25) | 8 (17) | 2 (13) |
| - Vitamin K Antagonists | 36 (26) | 7 (22) | 7 (16) | 2 (13) |
| - Direct Oral Anticoagulants | 2 (2) | 1 (1) | 1 (1) | 0 (0) |
| Antiplatelets | 68 (50) | 15 (47) | 17 (38) | 6 (38) |
All values presented as number (percentages), unless otherwise specified
Abbreviations: CMB = Cerebral Microbleeds, ICH = Intracerebral Hemorrhage, IQR = interquartile range, OAT = Oral Anticoagulation Therapy, SD = standard deviation