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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Stroke. 2020 Jun 10;51(7):2153–2160. doi: 10.1161/STROKEAHA.120.028310

Table 3.

Performance of Prediction Models for Risk of Recurrent ICH Following OAT-ICH

Model Variables Included C-statistic (95% CI) Statistical Comparison (p-value)
vs. Model 1 vs. Model 2 vs. Model 3
Model 1:
- Clinical		 • Clinical Data* 0.51 (0.48 – 0.54) - - -
Model 2:
- Clinical
- MRI		 • Clinical Data*
• CSS: Disseminated
• Lobar CMB		 0.70 (0.66 – 0.74) 0.011 - -
Model 3:
- Clinical
- APOE		 • Clinical Data*
• APOE ε2 or ε4 (≥ 1 copy)		 0.65 (0.61 – 0.70) 0.009 0.21 -
Model 4:
- Clinical
- MRI
- APOE		 • Clinical Data*
• CCS: Disseminated
• Lobar CMB
• APOE ε2 or ε4 (≥ 1 copy)		 0.79 (0.73 – 0.84) 0.002 0.012 0.033
*

Clinical data includes age and educational level.

Results derived from combined analysis of MGH-ICH and ERICH data (n = 230)

Abbreviations: 95% CI = 95% Confidence Interval, APOE = Apolipoprotein E, CSS = Cortical Superficial Siderosis, CMB = Cerebral Microbleeds, ICH = Intracerebral Hemorrhage, OAT = Oral Anticoagulation Therapy