. Author manuscript; available in PMC: 2021 Jul 1.

Published in final edited form as: J Immunol. 2020 May 15;205(1):90–101. doi: 10.4049/jimmunol.1901015

Table 2.

Number of splenic B cells in B6, Bak^−/−Bax^fl/fl, and Cd19Cre⁺Bak^−/−Bax^fl/fl mice¹

Cell populations (×10⁶)	B6	Bak^−/−Bax^fl/fl	Cd19Cre⁺Bak^−/−Bax^fl/fl
Total Splenocytes	96 (±22)²	120 (±23)	280 (±97)³^**
B220⁺CD93⁺ compartment
IgM^−/loCD23⁻	0.24 (±0.14)	0.4 (±0.15)	1.5 (±0.69)^**
T1	1.3 (±0.9)	1.8 (±0.66)	2.6 (±1.43)
T2	0.76 (±0.51)	1.4 (±0.81)	1.9 (±0.93)^*
T3	0.19 (±0.10)	0.31 (±0.23)	0.78 (±0.54)^*
B220⁺CD93⁻ compartment
MF	38 (±9.2)	48 (±10)	86 (±30)^**
MZ	2.6 (±0.32)	1.0 (±0.69)^*	0.12 (±0.06)^**
IgM^−/loIgD^hi anergic	1.8 (±0.94)	2.9 (±1.3)	19 (±12)^**
IgM⁻IgD⁻ switched	0.86 (±0.38)	1.0 (±0.28)	20 (±3.2)^**

^1;

Absolute cell numbers of indicated B-cell subsets in spleens of B6 (n = 4), Bak^−/−Bax^fl/fl (n = 4), and Cd19Cre⁺Bak^−/−Bax^fl/fl mice (n = 7) are shown.

^2;

Mean values (±SD) are shown.

^3;

*; P < 0.05; **, P < 0.01 compared with B6 control. Statistical significance was obtained by Mann-Whitney’s U test.