Table I.
Demographics, clinical characteristics, and laboratory findingsa
| Characteristics | Patient 1 |
|---|---|
| Age | 67 |
| Sex | Male |
| Relevant past medical history | None |
| Symptoms onset | Fever, dyspnea, fatigue, anasarca |
| Preoperative respiratory support | Noninvasive mechanical ventilation |
| LMWH prophylaxis | Enoxaparin 6,000 IU/day |
| Days from admission to thrombotic event | 5 |
| Event | Right acute limb ischemia secondary to iliac-femoro-popliteal arterial thrombosis |
| Intervention | Surgical thrombectomy |
| Intraoperative UFH to achieve ACT > 250 sec | 14,000 IU |
| Postoperative UFH infusion to achieve aPTT ratio > 2 | 2,000 IU/h |
| Admission | |
| Platelet count (×109/L) | 214,000 |
| Leukocytes (109/L) | 5.6 |
| Lymphocytes (109/L) | 0.9 |
| Hemoglobin (g/L) | 15.1 |
| Prothrombin time ratio | 0.96 |
| aPTT ratio | 1 |
| D-dimer (μg/mL) | 1.83 |
| Fibrinogen (mg/dL) | 711 |
| Preoperative | |
| Platelet count (×109/L) | 405 |
| Leukocytes (109/L) | 11.6 |
| Lymphocytes (109/L) | 0.6 |
| Hemoglobin (g/L) | 15.7 |
| Prothrombin time ratio | 1.06 |
| aPTT ratio | 0.84 |
| D-dimer (μg/mL) | >20 |
| Fibrinogen (mg/dL) | 740 |
| At last follow-up | |
| Platelet count (×109/L) | 285,000 |
| Leukocytes (109/L) | 8.4 |
| Lymphocytes (109/L) | 1.7 |
| Hemoglobin (g/L) | 13.3 |
| Prothrombin time ratio | 1.12 |
| aPTT ratio | 1.07 |
| D-dimer (μg/mL) | 1.60 |
| Fibrinogen (mg/dL) | 510 |
a
Reference ranges are as follows: platelet count, 150,000 to 450,000 per cubic millimeter; leukocytes, 4.8 to 10.8 per cubic liter; lymphocytes, 1 to 4.8 per cubic liter; hemoglobin, 14 to 18 grams per deciliter; normal prothrombin time ratio 0.9 to 1.18; normal activated partial-thromboplastin time, 0.75 to 1.29; D-dimer, 0.27–0.77 μg per milliliter; fibrinogen, 150 to 400 mg per deciliter.