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. 2020 Jun 19;13:1471–1483. doi: 10.2147/JPR.S251948

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© 2020 Wang et al.

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(A) Glutamate was injected into the left hind paw at 7 d after carrageenan injection. And MWT were measured before injection, 4, 72 h, 7 d after the 1^st injection and 1, 4, 24, 48 h after the 2^nd injection in all groups. (B) Glutamate increased the expression of PKCε protein in the L4-6 DRG by Western blot. (C) Pre-injection of MTEP inhibited the reduction of MWT induced by hyperalgesia (D, E) MTEP (mGluR5 inhibitor) decreased the expression of mGluR5 and PKCε protein in the L4-6 DRG. Data are presented as mean ± SEM, n=6; ^##P<0.01 vs N group; ^ΔΔP<0.01 vs sham HP group; *P<0.05, **P < 0.01 vs HP group.