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. 2020 Jun 23;10:10202. doi: 10.1038/s41598-020-67087-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of cyclic pulsations on aqueous outflow facility. The experimental anterior segment received IOP pulsations for 8 h. (A) The presence of experimentally induced cyclic mechanical stress significantly reduced the aqueous outflow facility as compared to its control (p = 0.003 (BL vs 24 hours); n = 6 pairs). Individual data points (black color dots) are indicated on the bar graph representing mean ± SEM. (B) Pairwise comparison between baseline and post cyclic pulsations for all treated pairs of eyes is represented. (C) Treatment with SB77 showed a significant increase in the outflow facility as compared to its control (p = 0.05 (BL vs 24 hours); n = 5 pairs). Individual data points (black color dots) are indicated on the bar graph representing mean ± SEM. **p < 0.005; *p < 0.05; Paired t-test. (D) Pairwise comparison of each pair of eyes received cyclic IOP pulsations in presence or absence of SB77 treatment is represented.