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. 2020 Jun 23;10:10154. doi: 10.1038/s41598-020-67103-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PGP 9.5 immunoreactive cells in scrotal skin in control (A–C) and melatonin treated group (D–F). Langerhans cells (arrows) were observed in the basal layer of epidermis which were much frequent in melatonin group (D) than control (A). Dendritic cells (arrow) in the dermis in control group and around the hair follicle (B & F), the sebaceous gland (D) as well as sweat glands (selected area in E). Notice, TCs around the outer root sheath of the hair follicle (selected area in C).