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. 2020 Jun 23;11:3172. doi: 10.1038/s41467-020-16911-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative flow cytometric plots showing gating of different HSPC subpopulations in bone marrow lineage negative cells from wild type mice 4 months after transplantation with 2 × 10⁶ BMMCs from control or mDia2^fl/fl Vav-Cre mice. b The percentages of indicated HSPC subpopulations in a. c The absolute number of indicated HSPCs in a. d Representative flow cytometric plots of cell cycle profile of LSK cells in a. e Quantitative analyses of d. n = 5 mice in mDia2^fl/fl, n = 6 in mDia2^fl/fl Vav-Cre for both b, c, and e. f Kaplan–Meier survival curve of mice transplanted with 2 × 10⁶ BMMCs from control or mDia2^fl/fl Vav-Cre mice. n = 17 mice in each group. g Kaplan–Meier survival curve of mice transplanted with 2 × 10⁶ BMMCs from primary transplanted mice in e. n = 7 mice in each group. h Kaplan–Meier survival curve of wild type mice transplanted with 2 × 10⁶ BMMCs from 2 years old control or mDia2^fl/fl Vav-Cre mice. n = 9 mice in mDia2^fl/fl group, n = 10 in mDia2^fl/fl Vav-Cre group. All the error bars represent the SEM of the mean. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Two-tailed unpaired Student’s t test was used to generate the p values. Significance for survival analyses in f–h was calculated by log-rank (Mantel–Cox) test.