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. 2020 Jun 23;10:10138. doi: 10.1038/s41598-020-66990-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Overall regulatory networks of miRNAs, circRNAs and mRNAs. (a) CircRNA-miRNA-mRNA interactions are potentially associated with the pathological process of AIS. ceRNA network prediction tools showed that some significant circRNA-miRNA-mRNA pairs may be involved in AIS associated with apoptotic pathways; these molecules included hsa_circ_0005548, hsa_circ_0000607 and hsa_circ_0020028, 101 miRNAs, and five mRNAs (Bax, Bcl2, Bcl2l2, BID, and Casp3). In the figure, blue circles represent miRNAs, red diamonds represent circRNAs and green rectangles represent mRNAs. (b) The possible binding miRNAs and mRNAs in hsa_circ_0000607-related AIS. One direct target of miR-337-3p was Bcl2, and hsa_circ_0000607 may potentially bind to hsa-miR-337-3p. Pathway analysis based on the hsa_circ_0000607/hs-miR-337-3p/Bcl2 network. The bioinformatic prediction of hsa_circ_0000607 target genes associated with AIS and apoptosis pathways and the miRNA-targeted mRNAs were predicted via TargetScan, miRanda and starBase.