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. 2020 Jun 23;10:10180. doi: 10.1038/s41598-020-67152-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD47 deficiency upregulates the expression of OSKM in intestinal epithelial cells. (a) Western blot analysis of OSKM expression in intestinal epithelial cells from WT and CD47^−/− mice treated with 2.5% DSS. (b) Overexpression or depletion of CD47 in CT26 cells reduced or enhanced the expression of OSKM factors, respectively. (c) Depletion of CD47 in HT29 cells enhanced the expression of OSKM. (d) Exogenous TSP1 can downregulate expression of Sox2, Oct4 and cMyc in HT29 cell line, but not Klf4. NS, no significance, *P < 0.05, **P < 0.01, ****P < 0.0001 versus WT or control.