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. 2020 Jun 23;11:3169. doi: 10.1038/s41467-020-16810-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a PCA of the metabolomes of glioma artery (gA) and dorsal pedal vein (P) samples from 13 patients. Three PCs explain 44.9% (15.1%, 17.5%, and 12.3%) of variance between gA and P. PC scores are indicated as %; circles indicate individual samples from the glioma artery and dorsal pedal vein. b VIP scores of metabolites between glioma artery(gA) and dorsal pedal vein (P) plasma samples. The names of the metabolites enriched in glioma arterial blood (gA) are labeled with blue text. The columns to the right indicate whether the abundance of each metabolite is enhanced (red box) or reduced (green box) in each plasma group. c Heatmap representation of 37 of 107 metabolites of blood plasma from glioma artery (gA) and dorsal pedal vein (P) samples. Warm color indicates higher concentration. d A heatmap representation of 37 metabolites (VIP score > 1) in blood samples from glioma artery (gA) and dorsal pedal vein (P). All metabolites are listed on the right side of the map. Color bar (bottom left), warm color indicates higher concenration. e Relative abundance (normalized by TIC, y-axis) of four representative metabolites (Acetylcholine, Allantoin, Imidazoleacetic acid, ADP) from glioma artery (gA) and dorsal pedal vein (P) samples. ***p < 0.001; two-tailed paired t-test. GlcN6P, Glucosamine 6-phosphate. CMP, Cytidine monophosphate. AMP, Adenosine monophosphate. ADP, Adenosine diphosphate.