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. 2020 Jun 23;10:10196. doi: 10.1038/s41598-020-67199-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Talazoparib enhances DSB induced by LuTate. AR42J cells were treated with single agents or in combination and assessed for ɣ-H2AX foci formation over 96 hr. (a) Representative images of cells stained for ɣ-H2AX are shown. Red, ɣ-H2AX; Blue, DAPI nuclear staining. (b) Five images per sample (minimum of 50 cells) were analysed and the average ɣ-H2AX foci per cell quantitated and expressed as mean ± SEM; n = 3; n.s. not significant, *P < 0.05, **P < 0.01.