Table 4.
Univariate and multivariable cox-proportional hazard analysis of clinicopathologic factors for biochemical recurrence free survival in three obesity sub-groups.
| “Normal” | “Overweight” | “Obese” | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariable | Univariate | Multivariable | Univariate | Multivariable | |||||||
| HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value | HR (95% CI for HR) | p.value | |
| Age (≥65 years) | 1.05 (0.69–1.59) | 0.83 | 1.18 (0.87–1.59) | 0.28 | 0.99 (0.56–1.75) | 0.96 | ||||||
| PSA | ||||||||||||
| <10 | Reference | Reference | Reference | Reference | Reference | Reference | ||||||
| 10–20 | 3.79 (2.61–5.50) | <0.01 | 1.93 (1.30–2.86) | <0.01 | 2.52 (1.91–3.33) | <0.01 | 1.82 (1.37–2.41) | <0.01 | 1.51 (0.80–2.86) | 0.20 | 1.15 (0.60–2.21) | 0.68 |
| >20 | 6.15 (4.12–9.19) | <0.01 | 1.92 (1.23–3.02) | <0.01 | 5.90 (4.46–7.81) | <0.01 | 2.56 (1.90–3.47) | <0.01 | 5.29 (3.07–9.13) | <0.01 | 2.35 (1.30–4.27) | <0.01 |
| Operation method (RALP) | 0.95 (0.67–1.23) | 0.75 | 0.64 (0.51–0.81) | <0.01 | 0.75 (0.59–0.95) | 0.01 | 0.49 (0.30–0.79) | 0.03 | 0.55 (0.33–0.90) | 0.02 | ||
| Surgical margin (Positive) | 3.71 (2.70–5.10) | <0.01 | 1.72 (1.21–2.46) | <0.01 | 2.85 (2.27–3.59) | <0.01 | 1.58 (1.22–2.03) | <0.01 | 2.49 (1.53–4.04) | <0.01 | 1.63 (0.95–2.78) | 0.08 |
| Gleason grade group | ||||||||||||
| 1 | Reference | Reference | Reference | Reference | Reference | Reference | ||||||
| 2 | 5.37 (2.43–11.88) | <0.01 | 3.22 (1.44–7.22) | <0.01 | 3.27 (2.02–5.28) | <0.01 | 2.30 (1.42–3.75) | <0.01 | 1.83 (0.73–4.62) | 0.20 | 1.46 (0.57–3.76) | 0.43 |
| 3 | 16.09 (7.36–35.14) | <0.01 | 6.85 (3.04–15.44) | <0.01 | 9.80 (6.16–15.60) | <0.01 | 5.34 (3.29–8.68) | <0.01 | 3.60 (1.44–8.98) | <0.01 | 2.52 (0.97–6.52) | 0.06 |
| 4 | 18.14 (7.61–43.21) | <0.01 | 7.38 (2.97–18.34) | <0.01 | 13.17 (7.53–23.03) | <0.01 | 8.20 (4.63–14.53) | <0.01 | 12.97 (4.76–35.35) | <0.01 | 7.68 (2.66–22.21) | <0.01 |
| 5 | 25.93 (10.95–61.40) | <0.01 | 7.16 (2.89–17.77) | <0.01 | 18.34 (10.82–31.08) | <0.01 | 6.98 (3.97–12.29) | <0.01 | 17.85 (6.64–48.00) | <0.01 | 8.77 (3.04–25.27) | <0.01 |
| Path_T_stage(T3 or over) | 5.40 (3.81–7.65) | <0.01 | 2.20 (1.47–3.30) | <0.01 | 3.65 (2.88–4.63) | <0.01 | 1.58 (1.20–2.08) | <0.01 | 3.76 (2.25–6.33) | <0.01 | 1.76 (0.97–3.19) | 0.06 |
| Patho_N | ||||||||||||
| N0 | Reference | Reference | Reference | Reference | Reference | Reference | ||||||
| N1 | 2.27 (1.44–3.56) | <0.01 | 1.33 (0.83–2.13) | 0.23 | 2.29 (1.58–3.31) | <0.01 | 0.26 | 3.26 (1.31–8.08) | 0.11 | 0.74 | ||
| NX | 0.33 (0.24–0.47) | <0.01 | 0.72 (0.49–1.04) | 0.08 | 0.41 (0.32–0.52) | <0.01 | 0.29 | 0.53 (0.31–0.91) | 0.20 | 0.28 | ||
| Path_LVI (Positive) | 4.46 (2.97–6.72) | <0.01 | 0.22 | 4.47 (3.33–6.01) | <0.01 | 1.60 (1.16–2.20) | <0.01 | 3.82 (2.12–6.89) | <0.01 | 0.71 | ||