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. 2020 Jun 23;10:10150. doi: 10.1038/s41598-020-66998-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Batch-effect correction improved the performance of DAR analysis. (A) Principle Component Analysis of rat Dentate Gyrus and Ammon’s Horn ATAC-seq data before (left) and after (right) batch effect correction. (B) Volcano plots of DARs identified between Dentate Gyrus and Ammon’s Horn before (left) and after (right) batch effect correction. X-axis indicates the ATAC-seq signal difference between Dentate Gyrus and Ammon’s Horn. Y-axis indicates -log₁₀(FDR). (C) GO enrichment analysis of genes around Dentate Gyrus (orange) and Ammon’s Horn (blue) DARs. (D) Principle Component Analysis of human healthy cartilage and osteoarthritis cartilage ATAC-seq data before (left) and after (right) batch effect correction. (E) Volcano plots of DARs identified between healthy cartilage and osteoarthritis cartilage before (left) and after (right) batch effect correction. (F) GO enrichment analysis of genes around osteoarthritis cartilage (orange) and human healthy cartilage (blue) DARs.