Skip to main content
. 2020 Jun 23;11:3168. doi: 10.1038/s41467-020-16971-6

Fig. 6. Loss of Piezo2 in proprioceptive neurons results in alternation of hip morphology.

Fig. 6

a Illustrations of the hip joints of control (left, normal joint) and Pvalb-Cre; Piezo2f/f (right, flattened type hip dysplasia) mice. Green arrow indicates femoral cam. b Ex vivo CT scans of P60 control (left, n = 5) and Pvalb-Cre; Piezo2f/f mice (right, n = 8) hip joints. Flattening of the upper acetabular rim is seen in the mutant. Green arrows point at a femoral cam. c Histological sections at show first signs of femoral cam in a P14 Pvalb-Cre; Piezo2f/f mouse with progression up to P60. Data are from three independent experiments. d 3D reconstruction of ex vivo CT scans show femoral cam (green arrow) in a P60 Pvalb-Cre; Piezo2f/f mouse. Data are from three independent experiments. e Graphs showing increased acetabular index and congruency index (at both upper and lower lips) upon ablation of Piezo2 in proprioceptive neurons. Control, n = 5 for all measurements; Pvalb-Cre; Piezo2f/f, n = 8 for 1.2 and n = 5 for 3.4. Statistical significance as determined by Welch’s two-sample t-test: 1, p = 0.013, 2, p = 0.133; 3, p = 0.001; 4, p = 0.002; asterisks indicate significant differences. Bar and whiskers represent mean value and SEM. Source data are provided as a Source Data file. Scale bars: 330 µm in (b), 590 µm in (c), 825 µm in (d, top), and 770 µm in (d, bottom).