Fig. 8. Loss of Runx3 in neural tissue results in hip dysplasia.
a Illustrations of the hip joint of control (left) and Wnt1-Cre;Runx3f/f mice (right). Runx3 cKO mouse exhibits flattened type hip dysplasia and femoral cam (green arrow). b Ex vivo CT scans of P60 control and Wnt1-Cre;Runx3f/f hip joints (n = 8 in both groups) show flattened upper acetabular rim and femoral cam in the mutant. c Graphs indicating increased acetabular index, decreased mean CEA and hip incongruence over both upper and lower sides of the joint in the cKO mice (n = 8 in both groups). Statistical significance as determined by Welch’s two-sample t-test: (1) p = 0.00006; (2) p = 0.0007; (3) p = 0.004; (4) p = 0.01; asterisks indicate significant differences. Bar and whiskers represent mean value and SEM. Source data are provided as a Source Data file. d 3D reconstruction of ex vivo CT scans at P60 show femoral cam (green arrow) and acetabular dysplasia in the cKO mice. Data are from three independent experiments. e Histological H&E-stained sections through P60 hip joints show femoral cam (green arrow) in the cKO mice. Data are from three independent experiments. Scale bars: 365 µm in b, 815 µm in d, and 230 µm in e.