Fig. 9. Loss of muscle spindle alone results in hip dysplasia of reduced severity.
a Ex vivo CT scans of P60 control (left, n = 7) and Egr3 KO (right, n = 14) mice show flattening of upper acetabular rim and femoral cam (green arrow) in the mutant. b 3D reconstruction of ex vivo CT scans at P60 show femoral cam (green arrow) and acetabular dysplasia in the Egr3 KO mice. Data are from three independent experiments.(c) Histological H&E-stained sections through P60 hip joints show femoral cam (green arrow) in the Egr3 KO mice. Data are from three independent experiments. d Graphs indicating increased CEA, increased mean acetabular index and hip incongruence over both upper and lower sides of the joint in the Egr3 KO mice (ncontrol = 7; nKO = 14). Statistical significance as determined by Welch’s two-sample t-test: (1) p = 0.68; (2) p = 0.001; (3) p = 0.014; (4) p = 0.002; asterisks indicate significant differences. Bar and whiskers represent mean value and SEM. Source data are provided as a Source Data file. Scale bars: 270 µm in (a), 825 µm in (b, top), 805 µm in (b, bottom), and 350 µm in c.