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. 2020 Jun 6;23(3):493–513. doi: 10.1007/s10456-020-09726-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Loss of RHOQ disrupted retinal vasculature formation. a RHOQ (red) is expressed in endothelial cells (CD31, green), and other cell types, in the central vasculature and at the leading edge in retinas obtained from day 6 old pups. b Retinas were transfected following intraocular injection of 500 nM in 1 ul of SiControl (SiC) or SiRHOQ mouse duplexes using the in vivo GFP-labelled JETPEI delivery system on day 3 following birth of pups and eyes harvested on day 6 following birth and effects on vasculature assessed by immuno-fluorescence staining by analysis of quadrants formed at both central and leading edge vasculature and open endpoints of cells that failed to form a connection with quadrant in the central vasculature. (White arrow, example of co-localisation; Scale bar = 20 nm; data representative of n = 3 independent experiments)