Table 3.
Categorization of gene promoters with differentially methylated (DM) CpGs associated with KRAS overexpression in SAKRAS lung cell line.
| SAKRAS cells | |||
|---|---|---|---|
| Hyper- methylated |
Hypo- methylated |
||
| Transcription Factors | |||
| BARHL2 | HOXA5 | AFF2 | OTX1 |
| BARX2 | IRX1 | BRDT | PAX2 |
| C11orf9 | IRX3 | CITED1 | PAX9 |
| CDX1 | KEAP1 | CRIP1 | SALL1 |
| CDX2 | KLF11 | ELF4 | SIM2 |
| CTNNB1 | MYBL2 | EMX1 | SNAPC2 |
| ETV7 | NKX2-3 | FOXC2 | SOX1 |
| FEZF2 | NKX6-2 | FOXG1 | SOX11 |
| FHL2 | PAX7 | FOXO4 | SOX3 |
| FOXA2 | POU3F2 | GSC | TAF1 |
| GATA5 | PRDM2 | HEYL | TBX1 |
| GBX2 | SOX21 | HIC1 | TBX2 |
| HAND1 | TBX3 | HOXA9 | TBX4 |
| HES5 | ULK2 | HSF4 | TLX2 |
| HES6 | UNCX | ISL2 | TSC22D3 |
| HHEX | UTF1 | LHX2 | ZFP161 |
| HNF1B | VAX1 | LMX1A | ZIC3 |
| HOXA2 | ZIM2 | NFYB | ZNF132 |
| NKRF | ZNF318 | ||
| OLIG2 | ZNF630 | ||
| Cytokines & Growth Factors | |||
| APLN | ADM2 | NGF | |
| CMTM2 | EDN3 | NPY | |
| FGF22 | FGF13 | OXT | |
| NPPC | GAL | STC2 | |
| PYY | GDF7 | ||
| Homeodomain Proteins | |||
| BARHL2 | IRX1 | EMX1 | |
| BARX2 | IRX3 | GSC | |
| CDX1 | NKX2-3 | HOXA9 | |
| CDX2 | NKX6-2 | ISL2 | |
| GBX2 | PAX7 | LHX2 | |
| HHEX | POU3F2 | LMX1A | |
| HNF1B | UNCX | OTX1 | |
| HOXA2 | VAX1 | PAX2 | |
| HOXA5 | TLX2 | ||
| Protein Kinases | |||
| CSNK1D | BRDT | MST4 | |
| EPHA8 | CDKL5 | PDK3 | |
| FLT1 | FASTK | RPS6KA3 | |
| GUCY2D | IRAK3 | TAF1 | |
| STK32C | MAPK4 | ||
| ULK2 | |||
| Oncogenes | |||
| CDX2 | ELF4 | MSI2 | |
| CTNNB1 | FOXO4 | OLIG2 | |
| FEV | GNAS | SEPT9 | |
| PAX7 | HOXA9 | TCL1A | |
| Cell Differentiation Markers | |||
| FUT4 | CD151 | ||
| GP1BB | CD8A | ||
| IL13RA1 | |||
| PTPRJ | |||
| Tumor Suppressors | |||
| BRCA1 | FAM123B | ||