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. 2020 Jun 23;10:10188. doi: 10.1038/s41598-020-67243-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The IRE1-sXBP1 pathway is activated NSCLC and correlate with tumor aggressiveness. A. Box and whiskers plots representing the amount of sXBP1 transcripts measured by fragments analysis in NSCLC tumor samples, classified according to the histological type of cancer. sXBP1 expression is calculated as sXBP1 peak intensity/(sXBP1 + XBP1 peak intensity). Oneway analysis of variance. B. Box and whiskers plots representing the amount of CHOP transcripts measured by RT-qPCR in NSCLC tumor samples, classified according to the histological type of cancer. CHOP relative expression levels are measured as cycle thresholds normalized to endogenous gene control (Ct). Oneway analysis of variance. C. Box and whiskers plots representing the amount of sXBP1 transcripts measured by fragments analysis in NSCLC tumor samples, classified according to the size and extend of the tumor. sXBP1 expression is calculated as sXBP1 peak intensity/(sXBP1 + XBP1 peak intensity). Oneway analysis of variance. D. Box and whiskers plots representing the amount of CHOP transcripts measured by RT-qPCR in tumor samples, classified according to the stage of the tumor. CHOP relative expression levels are measured as cycle thresholds normalized to endogenous gene control (Ct). Oneway analysis of variance. E. Box and whiskers plots representing the amount of sXBP1 transcripts measured by fragments analysis in NSCLC tumor samples, classified according to the stage of the tumor. sXBP1 expression is calculated as sXBP1 peak intensity/(sXBP1 + XBP1 peak intensity). Oneway analysis of variance. F. Box and whiskers plots representing the amount of CHOP transcripts measured by RT-qPCR in tumor samples, classified according to the size and extend of the tumor. CHOP relative expression levels are measured as cycle thresholds normalized to endogenous gene control (Ct). Oneway analysis of variance. G. Kaplan-Meier curves for the association between the amount of sXBP1 transcripts in tumor samples and disease-free survival in the cohort of 165 patients with NSCLC, according to highest (red curve) and lower (bleu curve) quartiles of sXPB1 distribution, measured as sXBP1 peak intensity/(sXBP1 + XBP1 peaks intensity). Wilcoxon test. H. Kaplan-Meier curves for the association between the amount of CHOP transcripts in tumor samples and disease-free survival in the cohort of 165 patients with NSCLC, according to highest (red curve) and lower (bleu curve) quartiles of CHOP distribution. Wilcoxon test.