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. 2020 Jun 23;11:3173. doi: 10.1038/s41467-020-16902-5

Fig. 5. Caspase-9 inhibitor reduces edema and rescues retinal morphology after RVO.

Fig. 5

a OCT measure of total retinal thickness in Pen1-treated control eyes (n = 18), and 24 h post-RVO in eyes treated with Pen1 (n = 22), Pen1-XBir3 (n = 26), Pen1-XBir3 (inactive mutant) (n = 12), and XBir3 (unlinked) (n = 14). One-way ANOVA with Fisher’s LSD; mean ± SEM. b Quantification of the fraction of veins occluded immediately after induction of RVO, and at 4 h, 24 h, and 48 h post-RVO. (RVO + Pen1, n = 39, 19, 28, 20) (RVO + Pen1-XBir3, n = 52, 18, 31, 25) two-tailed Welch’s t test; mean ± SEM. c Fluorescein angiography, OCT, and fundus retinal imaging of eyes treated with Pen1 (n = 5) or Pen1-XBir3 (n = 7) following induction of RVO, imaged at 24 h, 48 h, and 8 days (white asterisks (*) = vein occlusions) and uninjured Pen1-treated (n = 12) and Pen1-Xbir3-treated (n = 12) eyes. d Fluorescein leakage quantification from (c); two tailed Welch’s t test; mean ± SEM. e Quantification of changes in average OCT retinal thickness in specific retinal layers relative to baseline thickness of uninjured controls. RVO + Pen1 (n = 10, 21, 14, 16), RVO + Pen1-XBir3 (n = 12, 26, 16, 14) at 4 h, 24 h, 48 h, and 8 days; two-tailed Welch’s t test; mean ± SEM. Source data are provided as a Source Data file.